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Cov kws tshaj lij Shan Yang pab pawg tau ua qhov kev ua tiav tshiab hauv kev tshawb fawb ntawm Neohesperidin Dihydrochalcone

Sijhawm: 2023-09-28 Ntaus: 31

Nrog rau kev txhim kho hauv kev ua neej nyob, peb cov khoom noj tau hloov pauv ntau. High-qab zib, cov zaub mov muaj roj yog maj mam dominating. Kev noj zaub mov kom ntev ntev yuav ua rau muaj cov roj (cholesterol) ntau ntxiv (TC) thiab triglycerides (TG), nrog rau kev cuam tshuam ntawm glycolipid metabolism. Neohesperidin Dihydrochalcone (NHDC) yog lub zog tshiab lub zog qab zib uas tau los ntawm citrus uas tseem muaj zog antioxidant thiab dawb radical scavenging kev ua ub no. Tsis ntev los no, pab neeg tshawb fawb ntawm Academician Shan Yang tau ua ib qho kev hloov tshiab hauv kev tshawb fawb ntawm Neohesperidin Dihydrochalcone (NHDC) los txhim kho glycolipid metabolism cuam tshuam los ntawm kev noj zaub mov muaj roj, thiab cov txiaj ntsig cuam tshuam yog "Neohesperidin Dihydrochalcone Ameliorates High-FatDiet- Induced Glycolipid Metabolism Disorder in Rats" Lub npe tau luam tawm nyob rau hauv Phau ntawv Journal of Agricultural thiab Food Chemistry, ib phau ntawv xov xwm saum toj kawg nkaus hauv kev ua liaj ua teb thiab hav zoov science thiab zaub mov, thiab 2019 tus kws kho mob cov tub ntxhais kawm ntawm peb lub koom haum tau los ua thawj tus sau ntawv. , Academician Shan Yang thiab Associate Professor Yang Guliang yog cov kws sau ntawv, thiab Longping ceg ntawm Graduate School ntawm Hunan University yog thawj chav. Cov kev tshawb fawb tau txhawb nqa los ntawm Hunan Kanglu Biomedical Technology Innovation thiab Entrepreneurship Team thiab Central Guidance Local Science thiab Technology Development Fund (2022ZYC044). 

Txoj kev tshawb no tau ua los ntawm kev muab nas rau ntawm kev sim noj zaub mov muaj roj ntau rau NHDC. Cov txiaj ntsig tau pom tias NHDC txo qis FPG thiab FPI qib, thiab NHDC tau tswj hwm cov qib qhia ntawm GLUT-4 thiab IRS-1 cov proteins. Nyob rau hauv cov nqe lus ntawm kev tiv thaiv kab mob, txoj kev tshawb fawb pom tau hais tias theem qhia ntawm cov protein tseem ceeb nyob rau hauv TLR4 / MyD88 / NF-κB txoj kev tau poob qis heev tom qab kev kho NHDC. Hais txog lub zog metabolism txoj hauv kev, NHDC tau txhawb nqa qib phosphorylation ntawm AMPK hauv daim siab cov ntaub so ntswg thiab txhawb kev qhia ntawm SIRT1 thiab PGC-1α. Nws tau pom tias NHDC tau txo qis qhov txawv txav ntawm cov ntshav lipid metabolism vim yog kev noj zaub mov muaj roj ntau los ntawm kev txhawb nqa lub cev lub zog metabolism. Nyob rau tib lub sijhawm, NHDC kev kho mob tau txo qis ntawm daim siab rog vim los ntawm kev noj zaub mov muaj rog, txhim kho ileal pathological puas tsuaj, nce SCFA qib, thiab nce qib ntawm plab hnyuv.

Los ntawm txoj hnyuv microbiota sequencing thiab kev txheeb xyuas kev sib raug zoo, nws tau pom tias kev ua haujlwm ntawm NHDC hauv kev txo qis cov piam thaj thiab lipid metabolism tshwm sim los ntawm kev noj zaub mov muaj roj muaj feem cuam tshuam rau kev tswj cov kab mob hauv plab hnyuv, txo qis qhov mob, thiab txhawb kev sib txuas ntawm SCFA. .

Txoj kev tshawb no tshawb xyuas cov txiaj ntsig ntawm NHDC ntawm qhov txawv txav ntawm cov ntshav lipid metabolism vim yog kev noj zaub mov muaj roj ntau thiab nws cov txheej txheem ua tau. Nws muab lub tswv yim tshiab rau kev txhim kho thiab kev siv NHDC cov piam thaj hloov pauv.

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Daim duab 1 NHDC kev kho mob inhibited rog vim los ntawm kev noj zaub mov muaj roj ntau hauv cov nas 


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Daim duab 2 Cov teebmeem ntawm NHDC ntawm daim siab pathology thiab cov ntshav lipid qib hauv cov nas uas muaj roj ntau 

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